Recently, Prof. WANG Hui, together with Prof. LIN Wenchu and associate Prof. QIAN Junchao from Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences reported a NIR- II -responsive carbon-coated iron oxide nanocluster which was guided by magnetic resonance image and capable of combined photothermal and chemodynamic therapy (CDT).
Relevant results were published in SCIENCE CHINA Materials.
As a promising treatment strategy, CDT has become a hot spot in treating cancer because of its simple operation and low side effects. The basic principle of CDT is that the nanozymes activate intracellular Fenton reaction, leading to the over-production of hydroxyl radicals that are toxic to cancer cells. Magnetite nanocrystals are widely used as Fenton reagents due to their non-invasive imaging ability and good biocompatibility. However, the ferromagnetic behavior and easy oxidization of magnetite nanocrystals bring about colloidal instability as nanozymes and limit the imaging-guided cancer therapy in practical application.
In this research, the team used a one-step solvothermal method to produce carbon-coated magnetite nanoclusters (CCMNCs) with optical absorption in the NIR-II(1000-1100 nm) by tuning the cluster structure and carbon coating of magnetite nanocrystals.
"The CCMNCs possess superparamagnetic nature and a rapid magnetic response for separation, enabling them as a contrast agent for T2-weighted MRI," said WANG Hui, who led the team.
He further explained how the CCMNCs worked. Fe2+ and Fe3+ could be found in the dissolution of CCMNCs in tumor microenvironment. Fe2+ produced ·OH in situ in cells and mice, which in turn killed cancer cells and inhibited tumor growth through CDT effects. Fe3+ could reduce intracellular glutathione (GSH) levels and enhance the deleterious effects caused by ·OH, thus improving CDT efficiency.
They concluded that the CCMNCs could effectively absorb and convert NIR-II irradiation into cytotoxic heat, enhancing tumor CDT efficiency and producing synergistic therapeutic effects.
This research work was supported by the National Key R&D Program of China, National Natural Science Foundation of China, Hefei Institutes of Physical Science Director's Fund, Collaborative Innovation Program of Hefei Science Center of CAS, Anhui Provincial Natural Science Foundation, Hefei Municipal Natural Science Foundation.
Schematic diagram of the CCMNCs for MR imaging, NIR-II-induced PTT-enhanced CDT. (Image by LIN Yefeng)
